The films of Brian M. Cassidy and Melanie Shatzky have screened at the Sundance, Berlin, Toronto, Locarno and Rotterdam film festivals, The Museum of Modern Art, The National Gallery of Art, Le Musée de la Civilisation, ICA London, The Museum of the Moving Image and Lincoln Center. In 2012, they were nominated for a Gotham Award for Breakthrough Director and won the Best New Talent Award from Québec/Canada at RIDM. The have held fellowships at the MacDowell Colony, Yaddo and the IFP Film Labs. Their feature debut, Francine, starring Academy Award winner Melissa Leo, was called "a smell gem of bleak neorealist portraiture" by The New York Times and was selected as a New York Times Critics' Pick. Their documentary, The Patron Saints, was called "one of the most powerful Canadian documentaries of recent years" by POV Magazine.

Cassidy & Shatzky also maintain an active photography practice and have had their work featured in GUP Magazine, Der Greif, It's Nice That, Wired, FlakPhoto, and Slate, among others. In 2015, RIDM invited the duo to guest curate "A Photographer's Eye: Photography & The Poetic Documentary", a special programme about the intersection of photography and documentary film, which was showcased at La Cinémathèque Québécoise.